Principal Scientist - ADC Biology
- United States - Washington – Bothell
Our Purpose
Our Values
Benefits
WHY PATIENTS NEED YOU
At Pfizer we deliver breakthroughs that change patients’ lives. The ADC Biology team plays a vital role in this mission through discovering and advancing novel ADCs while utilizing comprehensive biological evaluation of tumor associated antigens and linker payloads. To discover the next generation of therapeutics, we are seeking a highly collaborative scientific leader with expertise in cancer cell biology.
POSITION SUMMARY
The successful candidate will be responsible for designing and executing preclinical discovery research activities in collaboration with cross functional project teams for drug development candidates. This individual will directly contribute to Pfizer Oncology pipeline and will be expected to drive collaborative efforts with cancer biologists, immunologists, chemists, and protein engineers to innovate and develop first-in-class oncology therapies. The successful candidate should have a record of being a strong scientist, team player, strategic thinker, and an effective communicator. This position will be responsible for directly mentoring and managing others including scientists and/or associates.
KEY RESPONSIBILITIES
Design, conduct, interpret and document experiments utilizing a diverse array of techniques aimed at identifying and characterizing novel tumor associated antigens and evaluating novel antibody drug conjugates (ADC) payloads
Execute molecular and cell-based methodologies including flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, western blotting, WES and in vitro PD assays
Leverage cell surface target biology to guide therapeutic design and identify the appropriate preclinical models for therapeutic design validation
Design and execute comprehensive experimental plans that inform and enable project progression. Define clear go/no go criteria for projects in alignment with overall research and corporate strategy
Lead and/or co-lead project teams and serve as a subject matter expert in cancer biology. Stay abreast of relevant literature and act as an expert resource within research
Work independently and demonstrate the ability to collaboratively contribute to projects outside their own expertise
Present research results and methodologies at weekly meetings with immediate supervisor and/or project leader, project team meetings and other research forums.
Coach and mentor people for performance and scientific growth
Contribute to building a culture that embraces scientific excellence, urgency, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific development
QUALIFICATIONS
Must-Have
Ph.D. in Cancer Biology, Biological Sciences, Biochemistry, Engineering, Immunology or a related field
5+ years of relevant postdoctoral and/or industry R&D/drug discovery experience
Expertise in oncology, cancer biology and cancer drug discovery
Ability to adapt and adjust to a rapidly evolving environment
Ability to identify and plan critical path experiments in alignment with team objectives
Uses critical thinking to solve complex problems, address challenges and overcome obstacles
Understanding of appropriate statistical design and analysis for pre-clinical experiments
Highly effective interpersonal skills, ability to identify and absorb critical information and convey it to relevant stakeholders
Strong written and verbal communication skills with the ability to communicate effectively to a wide range of audiences
Nice-to-Have
2-5 years of experience leading projects/programs in a biotechnology or pharmaceutical company focused on oncology discovery and drug development
Expertise in ADC discovery or cancer signaling is preferred
Prior experience managing scientists and associates
Relocation support available
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Breakthroughs that change patients’ lives
Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.
Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:
“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.
“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.
“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.
Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.
Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.
Our Values
To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.
Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.
Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.
Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.
Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.
Benefits at Pfizer
Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.
Our Competitive Benefits Programs help our colleagues by:
- Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
- Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
- Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
- And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.
For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)